4-(Difluoromethoxy)phenylacetonitrile

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For R&D use only.

Catalog NO.：A1685
CAS No. : 41429-16-7
Molecular Formula：C₉H₇F₂NO
Molecular Weight： 183.16

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	41429-16-7	Appearance	Colorless liquid
Catalog Number	A1685	MDL Number	MFCD00236242
Molecular Formula	C₉H₇F₂NO	Molecular Weight	183.16
Boiling Point	262.4°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	2-(4-(difluoromethoxy)phenyl)acetonitrile
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H312-H319-H332	Class
Precautionary Statements	P280-P310-P305+P351+P338	Packing Group

Description

MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). MGL-3196 shows outstanding safety in a rat heart model and is efficacious in a preclinical model at doses that showed no impact on the central thyroid axis.

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