4-(Tert-Butyl)aniline

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For R&D use only.

Catalog NO.：A838933
CAS No. : 769-92-6
Molecular Formula：C₁₀H₁₅N
Molecular Weight： 149.24

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	769-92-6	Appearance	Light yellow liquid
Catalog Number	A838933	MDL Number	MFCD00007899
Molecular Formula	C₁₀H₁₅N	Molecular Weight	149.24
Boiling Point	90-93°C at 3 mmHg	Melting Point	15-16°C
Flash Point	101°C	Density	0.937
Synonyms	4-(Tert-Butyl)aniline
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.

1422144-42-0 (mesylate)

1254032-66-0 (free base)

1253952-02-1 (HCl)

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