(2,2,2-Trifluoroethyl)hydrazine

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For R&D use only.

Catalog NO.：A828116
CAS No. : 5042-30-8
Molecular Formula：C₂H₅F₃N₂
Molecular Weight： 114.07

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	5042-30-8	Appearance	Colorless or yellowish solution
Catalog Number	A828116	MDL Number	MFCD00007622
Molecular Formula	C₂H₅F₃N₂	Molecular Weight	114.07
Boiling Point	83.1°C at 760 mmHg	Melting Point
Flash Point	42.8oC	Density	1.261 g/cm3
Synonyms	(2,2,2-Trifluoroethyl)hydrazine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	1993
Hazard Statements	H226-H302-H312-H315-H319-H332-H335	Class	3
Precautionary Statements	P210-P261-P305+P351+P338	Packing Group	Ⅲ

Description

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

1231929-97-7 (free base)

1231930-82-7 (mesylate)

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H200	Explosives (Unstable Explosive)
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