Delanzomib
- Catalog NO.:A857827
- CAS No. : 847499-27-8
- Molecular Formula:C21H28BN3O5
- Molecular Weight: 413.21
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 847499-27-8 | Appearance | Off-white powder |
Catalog Number | A857827 | MDL Number | MFCD18251439 |
Molecular Formula | C21H28BN3O5 | Molecular Weight | 413.21 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H317-H319 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
Delanzomib, also known as CEP-18770, is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. |