SAR407899
- Catalog NO.:A903661
- CAS No. : 923359-38-0
- Molecular Formula:C14H16N2O2
- Molecular Weight: 244.29
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Product Details
CAS Number | 923359-38-0 | Appearance | |
Catalog Number | A903661 | MDL Number | |
Molecular Formula | C14H16N2O2 | Molecular Weight | 244.29 |
Boiling Point | 517.8±50.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity. SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. SAR407899 is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. SAR407899 is approximately 8-fold more active than fasudil. SAR407899 potently (mean IC(50) values: 122 to 280 nM) and species-independently relaxed precontracted isolated arteries of different species and different vascular beds. The antihypertensive effect of SAR407899 was superior to that of fasudil and Y-27632. |