For R&D use only.

7-Methoxy-1H-indole

  • Catalog NO.:A875773
  • CAS No. : 3189-22-8
  • Molecular Formula:C9H9NO
  • Molecular Weight: 147.18
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Product Details

CAS Number 3189-22-8 Appearance
Catalog Number A875773 MDL Number MFCD00047203
Molecular Formula C9H9NO Molecular Weight 147.18
Boiling Point 297.8°C at 760 mmHg Melting Point
Flash Point Density 1.126
Synonyms 7-Methoxy-1H-indole
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group

Description

Rosiptor, also known as AQX-​1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases.

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7-Methoxy-1H-indole
7-Methoxy-1H-indole