(4-(Chloromethyl)phenyl)(phenyl)sulfane

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For R&D use only.

Catalog NO.：A804609
CAS No. : 1208-87-3
Molecular Formula：C₁₃H₁₁ClS
Molecular Weight： 234.74

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Product Details

CAS Number	1208-87-3	Appearance	Brown liquid
Catalog Number	A804609	MDL Number	MFCD09907764
Molecular Formula	C₁₃H₁₁ClS	Molecular Weight	234.74
Boiling Point	372°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	(4-(Chloromethyl)phenyl)(phenyl)sulfane
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells.

1372540-25-4 (free base)

2108806-07-9 (HCl)

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H200	Explosives (Unstable Explosive)
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