4,6-Dichloropyrido[3,2-d]pyrimidine
- Catalog NO.：A881582
- CAS No. : 175358-02-8
- Molecular Formula：C7H3Cl2N3
- Molecular Weight： 200.02
1. Please click the
to confirm the discount and stock quantity.2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
| CAS Number | 175358-02-8 | Appearance | Off-white powder |
| Catalog Number | A881582 | MDL Number | MFCD11846204 |
| Molecular Formula | C7H3Cl2N3 | Molecular Weight | 200.02 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | 4,6-Dichloropyrido[3,2-d]pyrimidine | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
| GHS Pictogram |
|
||
| Signal Word | Warning | UN Number | |
| Hazard Statements | H302;H315;H319;H335 | Class | |
| Precautionary Statements | P261;P305+P351+P338 | Packing Group | |
Description
|
GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. |
