AMG900
- Catalog NO.:A859339
- CAS No. : 945595-80-2
- Molecular Formula:C28H21N7Os
- Molecular Weight: 503.58
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Product Details
CAS Number | 945595-80-2 | Appearance | Yellow powder |
Catalog Number | A859339 | MDL Number | MFCD18633194 |
Molecular Formula | C28H21N7Os | Molecular Weight | 503.58 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-(4-((3-(2-aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine.;AMG-900 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
AMG 900 is a novel class of ATP-competitive phthalazinamine small molecule inhibitors of aurora kinases. In HeLa cells, AMG 900 inhibits autophosphorylation of aurora-A and -B as well as phosphorylation of histone H3 on Ser, a proximal substrate of aurora-B. The predominant cellular response of tumor cells to AMG 900 treatment is aborted cell division without a prolonged mitotic arrest, which ultimately results in cell death. AMG 900 inhibits the proliferation of 26 tumor cell lines, including cell lines resistant to the antimitotic drug paclitaxel and to other aurora kinase inhibitors (AZD1152, MK-0457, and PHA-739358), at low nanomolar concentrations (about 2- 3 nM). Furthermore, AMG 900 is active in an AZD1152-resistant HCT116 variant cell line that harbors an aurora-B mutation (W221L). |