PD 173074
- Catalog NO.:A25450
- CAS No. : 219580-11-7
- Molecular Formula:C28H41N7O3
- Molecular Weight: 523.67
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Product Details
CAS Number | 219580-11-7 | Appearance | |
Catalog Number | A25450 | MDL Number | MFCD08705327 |
Molecular Formula | C28H41N7O3 | Molecular Weight | 523.67 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea;PD173074 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. |