RO4929097
- Catalog NO.:A857746
- CAS No. : 847925-91-1
- Molecular Formula:C22H20F5N3O3
- Molecular Weight: 469.41
Note*
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3. The price does not include shipping and bank charges.
Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 847925-91-1 | Appearance | Off-white solid |
Catalog Number | A857746 | MDL Number | MFCD18384976 |
Molecular Formula | C22H20F5N3O3 | Molecular Weight | 469.41 |
Boiling Point | 696.3±55.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | (S)-2,2-Dimethyl-N1-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N3-(2,2,3,3,3-pentafluoropropyl)malonamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
RO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation. |