RG-3039
- Catalog NO.:A897403
- CAS No. : 1005504-62-0
- Molecular Formula:C21H23Cl2N5O
- Molecular Weight: 432.35
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 1005504-62-0 | Appearance | |
Catalog Number | A897403 | MDL Number | MFCD28716151 |
Molecular Formula | C21H23Cl2N5O | Molecular Weight | 432.35 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | PF06687859;5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. |