NMS-873
- Catalog NO.:A885396
- CAS No. : 1418013-75-8
- Molecular Formula:C27H28N4O3S2
- Molecular Weight: 520.67
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 1418013-75-8 | Appearance | Light yellow solid |
Catalog Number | A885396 | MDL Number | |
Molecular Formula | C27H28N4O3S2 | Molecular Weight | 520.67 |
Boiling Point | 769.3±70.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | Pyridine, 3-[3-(cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]- | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
NMS-873 is a potent, allosteric and specific VCP inhibitor (also known as p97 inhibitor) with IC50 of 30 nM. NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target. |