GW-3965

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For R&D use only.

Catalog NO.：A846160
CAS No. : 405911-09-3
Molecular Formula：C₃₃H₃₁ClF₃NO₃
Molecular Weight： 582.06

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Product Details

CAS Number	405911-09-3	Appearance
Catalog Number	A846160	MDL Number	MFCD08272365
Molecular Formula	C₃₃H₃₁ClF₃NO₃	Molecular Weight	582.06
Boiling Point		Melting Point
Flash Point		Density
Synonyms	2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements		Class
Precautionary Statements		Packing Group

Description

GW-3965 is a liver X receptor agonist. GW3965 represses the production of pro-inflammatory cytokines by murine mast cells. GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro. GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages.

405911-17-3 (HCl)

405911-09-3 (free)

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P220	Keep/Store away from clothing/…/combustible materials.
P221	Take any precaution to avoid mixing with combustibles/…
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted with …
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool.
P240	Ground/bond container and receiving equipment.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
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P281	Use personal protective equipment as required.
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P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.

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P378	Use … for extinction.
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P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire: Use … for extinction.
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P401	Store …
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P402 + P404	Store in a dry place. Store in a closed container.
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P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Store at temperatures not exceeding … oC/…oF. Keep cool.

P501	Dispose of contents/container to..…
P502	Refer to manufacturer/supplier for information on recovery/recycling

GW-3965

Product Details

Safety

Description

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GW-3965
2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid

H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
H204	Explosives (Div 1.4)
H205	Explosives （Div 1.5)
H220	Flammable gases (Category 1)
H221	Flammable gases (Category 2)
H222	Flammable aerosols (Category 1)
H223	Flammable aerosols (Category 2)
H224	Flammable liquids (Category 1)
H225	Flammable liquids (Category 2)
H226	Flammable liquids (Category 3)
H227	Flammable liquids (Category 4)
H228	Flammable solids (Category 1)
H240	Self-reactive substances and mixtures; and Organic peroxides (Type A)
H241	Self-reactive substances and mixtures; and Organic peroxides (Type B)
H242	Self-reactive substances and mixtures; and Organic peroxides (Type C. D.)
H250	Pyrophoric liquids; Pyrorophoric solids (Category 1)
H251	Self-heating substances and mixtures (Category 1)
H252	Self-heating substances and mixtures (Category 2)
H260	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 1)
H261	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 2)
H261	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 3)
H270	Oxidising gases (Category 1)
H271	Oxidising liquids;Oxidising solids (Category 1)
H272	Oxidising liquids;Oxidising solids (Category 2)
H280	Gases under pressure Compressed gas Liquefied gas Dissolved gas
H281	Gases under pressure Refrigerated liquefied gas
H290	Corrosive to Metals (Category 1)

H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
H305	Aspiration hazard (Category 2)
H310	Acute toxicity,dermal (Category 1, 2)
H311	Acute toxicity,dermal (Category 3)
H312	Acute toxicity,dermal (Category 4)
H313	Acute toxicity,dermal (Category 5)
H314	Skin corrosion/irritation (Category 1A, B, C)
H315	Skin corrosion/irritation (Category 2)
H316	Skin corrosion/irritation (Category 3)
H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
H319	Serious eye damage/eye irritation (Category 2A)
H320	Serious eye damage/eye irritation (Category 2B)
H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
H350	Carcinogenicity (Category 1A, 1B)
H351	Carcinogenicity (Category 2)
H360	Reproductive toxicity (Category 1A, 1B)
H361	Reproductive toxicity (Category 2)
H362	Reproductive toxicity, effects on or via lactation (Additional category)
H370	Specific target organ toxicity, single exposure (Category 1)
H371	Specific target organ toxicity, single exposure (Category 2)
H372	Specific target organ toxicity, repeated exposure (Category 1)
H373	Specific target organ toxicity, repeated exposure (Category 2)

H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
H410	Hazardous to the aquatic environment, long-term hazard(Category 1)
H411	Hazardous to the aquatic environment, long-term hazard (Category 2)
H412	Hazardous to the aquatic environment, long-term hazard (Category 3)
H413	Hazardous to the aquatic environment, long-term hazard (Category 4)
H420	Hazardous to the ozone layer (Category 1)

GW-3965

Product Details

Safety

Description

Related Products

Batch search Close

GW-3965 2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid

GW-3965
2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid