OC000459
- Catalog NO.:A852622
- CAS No. : 851723-84-7
- Molecular Formula:C21H17FN2O2
- Molecular Weight: 348.37
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 851723-84-7 | Appearance | |
Catalog Number | A852622 | MDL Number | MFCD18633254 |
Molecular Formula | C21H17FN2O2 | Molecular Weight | 348.37 |
Boiling Point | 574.4±50.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | Timapiprant;2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Timapiprant, also known as OC000459, is a potent, selective and orally active CRTH2 antagonist. OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. OC000459 inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. OC000459 treatment inhibited LAR and post-allergen increase in sputum eosinophils. OC000459 appears to inhibit allergic inflammation in asthma. |