Cabozantinib-s-malate
- Catalog NO.：A856828
- CAS No. : 1140909-48-3
- Molecular Formula：C32H30FN3O10
- Molecular Weight： 635.59
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Product Details
| CAS Number | 1140909-48-3 | Appearance | |
| Catalog Number | A856828 | MDL Number | MFCD20923480 |
| Molecular Formula | C32H30FN3O10 | Molecular Weight | 635.59 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate;Cabozantinib Malate | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
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| Signal Word | Warning | UN Number | |
| Hazard Statements | H302-H315-H319-H335 | Class | |
| Precautionary Statements | P261-P305+P351+P338 | Packing Group | |
Description
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Cabozantinib malate (XL-184 or BMS-907351) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression. Cabozantinib was approved by the U.S. FDA in November 2012 for the treatment of medullary thyroid cancer. |
