PD-153035
- Catalog NO.:A15258
- CAS No. : 153436-54-5
- Molecular Formula:C16H14BrN3O2
- Molecular Weight: 360.21
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 153436-54-5 | Appearance | White to off-white solid |
Catalog Number | A15258 | MDL Number | MFCD00934896 |
Molecular Formula | C16H14BrN3O2 | Molecular Weight | 360.21 |
Boiling Point | 472.1°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | SU5271; AG-1517;N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;PD153035 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H332-H335 | Class | |
Precautionary Statements | P261-P280-P305+P351+P338 | Packing Group |
Description
PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). |