AZD-1208
- Catalog NO.:A892213
- CAS No. : 1204144-28-4
- Molecular Formula:C21H21N3O2S
- Molecular Weight: 379.48
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Product Details
CAS Number | 1204144-28-4 | Appearance | Off-white powder |
Catalog Number | A892213 | MDL Number | MFCD25976757 |
Molecular Formula | C21H21N3O2S | Molecular Weight | 379.48 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione;AZD1208 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies. |