Ezatiostat
- Catalog NO.:A882156
- CAS No. : 168682-53-9
- Molecular Formula:C27H35N3O6S
- Molecular Weight: 529.65
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Product Details
CAS Number | 168682-53-9 | Appearance | White powder |
Catalog Number | A882156 | MDL Number | MFCD27982957 |
Molecular Formula | C27H35N3O6S | Molecular Weight | 529.65 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | TLK 199;(S)-ethyl 2-amino-5-(((R)-3-(benzylthio)-1-(((S)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Ezatiostat is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity. After intracellular de-esterification, the active form of ezatiostat binds to and inhibits GST P1-1, thereby restoring Jun kinase and MAPK pathway activities and promoting MAPK-mediated cellular proliferation and differentiation pathways. This agent promotes the proliferation and maturation of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). |