LY2801653
- Catalog NO.:A857531
- CAS No. : 1206799-15-6
- Molecular Formula:C30H22F2N6O3
- Molecular Weight: 552.53
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Product Details
CAS Number | 1206799-15-6 | Appearance | |
Catalog Number | A857531 | MDL Number | MFCD23160048 |
Molecular Formula | C30H22F2N6O3 | Molecular Weight | 552.53 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Merestinib;N-(3-fluoro-4-((1-Methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxaMide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Merestinib, also known as LY2801653, is a n orally available, small molecule inhibitor of the proto-oncogene c-Met (mesenchymal-epithelial transition, also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor LY2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. This agent has potent anti-tumor efficacy in mono- and combination therapy in a broad range of cancers. |