KU 0060648
- Catalog NO.:A862311
- CAS No. : 881375-00-4
- Molecular Formula:C33H34N4O4S
- Molecular Weight: 582.71
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
COA
Product Details
CAS Number | 881375-00-4 | Appearance | |
Catalog Number | A862311 | MDL Number | MFCD17214218 |
Molecular Formula | C33H34N4O4S | Molecular Weight | 582.71 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide;KU-0060648 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Danger | UN Number | 2811 |
Hazard Statements | H301 | Class | 6.1 |
Precautionary Statements | P301+P310 | Packing Group | Ⅲ |
Description
Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kδ, PI 3-Kβ, PI 3-Kα and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ~2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%; maximum effect seen at 250 nM. |