For R&D use only.

AZD-9291

  • Catalog NO.:A854509
  • CAS No. : 1421373-65-0
  • Molecular Formula:C28H33N7O2
  • Molecular Weight: 499.61
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Quality Control&SDS
SDS COA NMR

Product Details

CAS Number 1421373-65-0 Appearance Yellow powder
Catalog Number A854509 MDL Number MFCD27988062
Molecular Formula C28H33N7O2 Molecular Weight 499.61
Boiling Point Melting Point
Flash Point Density
Synonyms N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide;Osimertinib
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group

Description

Osimertinib, also known as AZD-9291 and Mereletinib, is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Osimertinib was approved in Nov. 2015 by FDA.

1421373-65-0 (free base)

1421373-66-1 (mesylate)

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AZD-9291
N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide;Osimertinib