For R&D use only.

Ceritinib (LDK378)

  • Catalog NO.:A852144
  • CAS No. : 1032900-25-6
  • Molecular Formula:C28H36ClN5O3S
  • Molecular Weight: 558.14
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Quality Control&SDS
SDS COA NMR

Product Details

CAS Number 1032900-25-6 Appearance Off-white powder
Catalog Number A852144 MDL Number MFCD26142648
Molecular Formula C28H36ClN5O3S Molecular Weight 558.14
Boiling Point 720.7±70.0°C at 760 mmHg Melting Point
Flash Point Density
Synonyms 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302-H315-H320-H335 Class
Precautionary Statements P261-P280-P301+P312-P302+P352-P305+P351+P338 Packing Group

Description

Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it sending growth signals to cancer cells, which may stop them growing. Ceritinib was approved in April 2014.

1032900-25-6 (free base)

1380575-43-8 (2HCl)

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Ceritinib (LDK378)
5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine