AZD-7762
- Catalog NO.:A24980
- CAS No. : 860352-01-8
- Molecular Formula:C17H19FN4O2S
- Molecular Weight: 362.42
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Product Details
CAS Number | 860352-01-8 | Appearance | White solid |
Catalog Number | A24980 | MDL Number | MFCD12406007 |
Molecular Formula | C17H19FN4O2S | Molecular Weight | 362.42 |
Boiling Point | 547.6°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluorophenyl)thiophen-3-yl)urea;AZD7762 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H319 | Class | |
Precautionary Statements | P305+P351+P338 | Packing Group |
Description
AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication. |