Olaparib
- Catalog NO.:A9666
- CAS No. : 763113-22-0
- Molecular Formula:C24H23FN4O3
- Molecular Weight: 434.46
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Product Details
CAS Number | 763113-22-0 | Appearance | |
Catalog Number | A9666 | MDL Number | MFCD13185161 |
Molecular Formula | C24H23FN4O3 | Molecular Weight | 434.46 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | AZD-2281;KU59436;4-(3-(1-(cyclopropanecarbonyl)piperazine-4-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;4-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorobenzyl]phthalazin-1(2H)-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H301; H360; H372 | Class | |
Precautionary Statements | P264; P201; P202; P281; P260; P301+P310; P330; P308+P313; P314 | Packing Group |
Description
Olaparib, also known as AZD-2281 or KU-59436 , is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Olaparib was approved in 2014 for treating advanced ovarian cancer. |