Inauhzin
- Catalog NO.:A876068
- CAS No. : 309271-94-1
- Molecular Formula:C25H19N5Os2
- Molecular Weight: 469.58
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Product Details
CAS Number | 309271-94-1 | Appearance | White powder |
Catalog Number | A876068 | MDL Number | |
Molecular Formula | C25H19N5Os2 | Molecular Weight | 469.58 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H317 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice. |