RKI-1447
- Catalog NO.:A887942
- CAS No. : 1342278-01-6
- Molecular Formula:C16H14N4O2S
- Molecular Weight: 326.37
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 1342278-01-6 | Appearance | Yellow powder |
Catalog Number | A887942 | MDL Number | MFCD26142658 |
Molecular Formula | C16H14N4O2S | Molecular Weight | 326.37 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319 | Class | |
Precautionary Statements | P305+P351+P338 | Packing Group |
Description
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells. |