For R&D use only.

Atosiban

  • Catalog NO.:A843637
  • CAS No. : 90779-69-4
  • Molecular Formula:C14H12O2
  • Molecular Weight: 994.19
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Product Details

CAS Number 90779-69-4 Appearance
Catalog Number A843637 MDL Number MFCD00672436
Molecular Formula C14H12O2 Molecular Weight 994.19
Boiling Point 1469°C at 760 mmHg Melting Point
Flash Point Density
Synonyms acetic acid; N-[4-amino-1-[(2-amino-2-oxo-ethyl)carbamoyl]butyl]-1-[7-(2-amino-2-oxo-ethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-13-sec-butyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;(S)-N-((S)-5-amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Danger UN Number 2811
Hazard Statements H361 Class 6.1
Precautionary Statements P281 Packing Group

Description

Atosiban, also known as ORF 22164, RWJ 22164, is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. It was developed by Ferring Pharmaceuticals in Sweden and first reported in the literature in 1985. Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant adult women.

914453-95-5 (Atosiban acetate)

90779-69-4 (Atosiban free base)

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Atosiban
acetic acid; N-[4-amino-1-[(2-amino-2-oxo-ethyl)carbamoyl]butyl]-1-[7-(2-amino-2-oxo-ethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-13-sec-butyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;(S)-N-((S)-5-amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide