MC-Val-Cit-PAB-PNP
- Catalog NO.:A858280
- CAS No. : 159857-81-5
- Molecular Formula:C35H43N7O11
- Molecular Weight: 737.76
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Product Details
CAS Number | 159857-81-5 | Appearance | |
Catalog Number | A858280 | MDL Number | MFCD22200431 |
Molecular Formula | C35H43N7O11 | Molecular Weight | 737.76 |
Boiling Point | 1034.5±65.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 4-((S)-N-((S)-1-amino-1-oxo-5-ureidopentan-2-yl)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)benzyl (4-nitrophenyl) carbonate;Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate;Mc-Val-Cit-PABC-PNP | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug. * * * * * * Please also see similar products: #610235: MC-Val-Cit-PAB (ADC peptide linker) and #610234: MC-Val-Cit-PAB-PNP (ADC peptide linker); #620108 Val-cit-PAB-OH (ADC peptide linker). |