LEE011 Succinate
- Catalog NO.：A886491
- CAS No. : 1374639-75-4
- Molecular Formula：C27H36N8O5
- Molecular Weight： 552.63
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Product Details
| CAS Number | 1374639-75-4 | Appearance | |
| Catalog Number | A886491 | MDL Number | MFCD28167746 |
| Molecular Formula | C27H36N8O5 | Molecular Weight | 552.63 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | Ribociclib succinate;7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
| GHS Pictogram |
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| Signal Word | Danger | UN Number | 2811 |
| Hazard Statements | H301-H315-H319-H372-H400 | Class | 6.1 |
| Precautionary Statements | P273-P301+P310-P305+P351+P338-P314 | Packing Group | Ⅲ |
Description
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Ribociclib, also known as LEE011, is an experimental drug that is an inhibitor of cyclin D1/CDK4 and CDK6, and is being studied as a treatment for drug-resistant cancers. It was developed by Novartis and Astex Pharmaceuticals. Cyclin-dependent kinases (CDKs) 4 and 6 are enzymes that have been shown to promote cell division and multiplication in both normal and cancer cells. Many cancer cells have shown abnormalities that increase the activity of CDK, leading to the inactivation of certain tumor suppressor genes. This has led to the idea that inhibiting CDK4 will slow the growth of tumors by reactivating these tumor suppressors. When used in combination with other drugs such as an ALK or an MEK inhibitor, ribociclib has been shown to have a synergistic effect, resulting in improved responses |
