KB-R7943 mesylate

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For R&D use only.

Catalog NO.：A846159
CAS No. : 182004-65-5
Molecular Formula：C₁₇H₂₁N₃O₆S₂
Molecular Weight： 427.49

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Product Details

CAS Number	182004-65-5	Appearance
Catalog Number	A846159	MDL Number	MFCD00952138
Molecular Formula	C₁₇H₂₁N₃O₆S₂	Molecular Weight	427.49
Boiling Point		Melting Point
Flash Point		Density
Synonyms	2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

KB-R7943 is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 μM). KB-R7943 does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. KB-R7943 blocks opening of the mitochondrial permeability transition pore. KB-R7943 restores endothelium-dependent relaxation induced by advanced glycosylation end products in rat aorta. KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion.

182004-64-4 (free base)

182004-65-5 (mesylate)

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