WEHI-539
- Catalog NO.:A905323
- CAS No. : 1431866-33-9
- Molecular Formula:C31H29N5O3S2
- Molecular Weight: 583.72
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Product Details
CAS Number | 1431866-33-9 | Appearance | |
Catalog Number | A905323 | MDL Number | MFCD25372044 |
Molecular Formula | C31H29N5O3S2 | Molecular Weight | 583.72 |
Boiling Point | 827.6±75.0 °C(Predicted) | Melting Point | |
Flash Point | Density | 1.44±0.1 g/cm3(Predicted) | |
Synonyms | (E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
WEHI-539 is a highly potent and selective BCL-XL inhibitor. The prosurvival BCL-2 family protein BCL-X(L) is often overexpressed in solid tumors and renders malignant tumor cells resistant to anticancer therapeutics. WEHI-539 has high affinity (subnanomolar) and selectivity for BCL-X(L) and potently kills cells by selectively antagonizing its prosurvival activity. WEHI-539 will be an invaluable tool for distinguishing the roles of BCL-X(L) from those of its prosurvival relatives, both in normal cells and notably in malignant tumor cells, many of which may prove to rely upon BCL-X(L) for their sustained. |