Dovitinib
- Catalog NO.:A24080
- CAS No. : 405169-16-6
- Molecular Formula:C21H21FN6O
- Molecular Weight: 392.43
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Product Details
CAS Number | 405169-16-6 | Appearance | Yellow powder |
Catalog Number | A24080 | MDL Number | MFCD10565680 |
Molecular Formula | C21H21FN6O | Molecular Weight | 392.43 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Dovitinib, CHIR-258; CHIR 258; CHIR258; 1-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one; (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one; TKI258; TKI-258; TKI 258; Multitargeted RTK inhibitor | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Dovitinib, also known as TKI-258 or CHIR-258, is an orally bioavailable FGFR3 inhibitor, which strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. |