Desfesoterodine fumarate
- Catalog NO.：A904173
- CAS No. : 380636-50-0
- Molecular Formula：C26H35NO6
- Molecular Weight： 457.56
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Product Details
| CAS Number | 380636-50-0 | Appearance | |
| Catalog Number | A904173 | MDL Number | |
| Molecular Formula | C26H35NO6 | Molecular Weight | 457.56 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | PNU-200577 fumarate;(+)-N,N-Diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropylamine fumarate;(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol fumarate | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
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| Signal Word | Warning | UN Number | |
| Hazard Statements | Class | ||
| Precautionary Statements | Packing Group | ||
Description
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Desfesoterodine, also known as PNU-200577, is a major pharmacologically active metabolite of tolterodine, a new muscarinic receptor antagonist intended for the treatment of an overactive bladder. In vitro, PNU-200577 produced a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (KB = 0.84 nM; pA2 = 9.14). In vivo, PNU-200577 was significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol.kg-1, respectively; P < 0.01). |
