MCC950 sodium salt

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For R&D use only.

Catalog NO.：A901735
CAS No. : 256373-96-3
Molecular Formula：C₂₀H₂₃N₂NaO₅S
Molecular Weight： 426.46

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Quality Control&SDS

SDS COA HPLC/GC LC-MS/GC-MS NMR

Product Details

CAS Number	256373-96-3	Appearance	Off-White powder
Catalog Number	A901735	MDL Number	MFCD30478884
Molecular Formula	C₂₀H₂₃N₂NaO₅S	Molecular Weight	426.46
Boiling Point		Melting Point
Flash Point		Density
Synonyms	CP-456773 sodium salt;sodium salt of 1-(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]-urea;MCC950 sodium
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

CP-456773, also known as MCC950 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. MCC950 is a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease.

256373-96-3 (sodium)

210826-40-7 (free acid)

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