RQ 00203078
- Catalog NO.:A890212
- CAS No. : 1254205-52-1
- Molecular Formula:C21H13ClF6N2O5S
- Molecular Weight: 554.85
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 1254205-52-1 | Appearance | Off-white powder |
Catalog Number | A890212 | MDL Number | MFCD29049510 |
Molecular Formula | C21H13ClF6N2O5S | Molecular Weight | 554.85 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid;RQ-00203078 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
RQ-00203078 is a potent, selective and orally active TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). RQ-00203078 blocks TRPM8 activity and reduces the invasion potential of oral squamous carcinoma cell lines. RQ-00203078 (RQ) profoundly reduced such agonist-induced cation currents. TRPM8 is reportedly an important player in carcinogenesis in human prostate cancer. 6). |