PD-123319 TFA salt

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For R&D use only.

Catalog NO.：A888689
CAS No. : 130663-39-7
Molecular Formula：C₃₁H₃₂N₄O₃
Molecular Weight： 508.61

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	130663-39-7	Appearance	Yellow solid
Catalog Number	A888689	MDL Number	MFCD00896427
Molecular Formula	C₃₁H₃₂N₄O₃	Molecular Weight	508.61
Boiling Point	775.8°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	PD-123319 TFA; PD 123319 ditrifluoroacetate;(S)-1-(4-(dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2);PD123319
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

FIPI is a potent and selective phospholipase D inhibitor. FIPI attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. FIPI rapidly blocks in vivo PA production with subnanomolar potency. We were surprised to find that several biological processes blocked by 1-butanol are not affected by FIPI, suggesting the need for re-evaluation of proposed FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis.

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