RG108
- Catalog NO.:A871941
- CAS No. : 48208-26-0
- Molecular Formula:C19H14N2O4
- Molecular Weight: 334.33
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 48208-26-0 | Appearance | |
Catalog Number | A871941 | MDL Number | MFCD08705332 |
Molecular Formula | C19H14N2O4 | Molecular Weight | 334.33 |
Boiling Point | 670.3°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H317 | Class | |
Precautionary Statements | P280 | Packing Group |
Description
RG108 is a non-nucleoside DNA methyltransferase inhibitor (DNMT inhibitor). RG108 led to a significant dose and time dependent growth inhibition and apoptosis induction in LNCaP, 22Rv1 and DU145. LNCaP and 22Rv1 also displayed decreased DNMT activity, DNMT1 expression and global DNA methylation. Interestingly, chronic treatment with RG108 significantly decreased GSTP1, APC and RAR-β2 promoter hypermethylation levels, although mRNA reexpression was only attained for GSTP1 and APC. RG108 is an effective tumor growth suppressor in most PCa cell lines tested. |