Lapatinib ditosylate

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For R&D use only.

Catalog NO.：A873769
CAS No. : 388082-77-7
Molecular Formula：C₄₃H₄₂ClFN₄O₁₀S₃
Molecular Weight： 925.46

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Product Details

CAS Number	388082-77-7	Appearance
Catalog Number	A873769	MDL Number	MFCD09264195
Molecular Formula	C₄₃H₄₂ClFN₄O₁₀S₃	Molecular Weight	925.46
Boiling Point	750.7°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine ditosylate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H332-H335	Class
Precautionary Statements	P261-P280-P305+P351+P338	Packing Group

Description

Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Check for active clinical trials or closed clinical trials using this agent.

388082-77-7 (ditosylate)

231277-92-2 (free base)

388082-78-8（ditosylate monohydrate）

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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