EHop-016

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For R&D use only.

Catalog NO.：A886323
CAS No. : 1380432-32-5
Molecular Formula：C₂₅H₃₀N₆O
Molecular Weight： 430.55

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Product Details

CAS Number	1380432-32-5	Appearance	Pale yellow solid
Catalog Number	A886323	MDL Number	MFCD23143628
Molecular Formula	C₂₅H₃₀N₆O	Molecular Weight	430.55
Boiling Point		Melting Point
Flash Point		Density
Synonyms	N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

EHop-016 is a novel potent and selective inhibitor of RAC. EHop-016 inhibits Rac activity in the MDA-MB-435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity. The IC(50) of 1.1 μM for Rac inhibition by EHop-016 is ~ 100-fold lower than for NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of < 5 μM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. EHop-016 also inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac downstream effects of PAK1 (p21-activated kinase 1) activity and directed migration of metastatic cancer cells. EHop-016 holds promise as a targeted therapeutic agent for the treatment of metastatic cancers with high Rac activity.

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P221	Take any precaution to avoid mixing with combustibles/…
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
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P263	Avoid contact during pregnancy/while nursing.
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P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
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P285	In case of inadequate ventilation wear respiratory protection.
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire: Use … for extinction.
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P501	Dispose of contents/container to..…
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EHop-016

Product Details

Safety

Description

Related Products

Batch search Close

EHop-016
N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine

H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
H204	Explosives (Div 1.4)
H205	Explosives （Div 1.5)
H220	Flammable gases (Category 1)
H221	Flammable gases (Category 2)
H222	Flammable aerosols (Category 1)
H223	Flammable aerosols (Category 2)
H224	Flammable liquids (Category 1)
H225	Flammable liquids (Category 2)
H226	Flammable liquids (Category 3)
H227	Flammable liquids (Category 4)
H228	Flammable solids (Category 1)
H240	Self-reactive substances and mixtures; and Organic peroxides (Type A)
H241	Self-reactive substances and mixtures; and Organic peroxides (Type B)
H242	Self-reactive substances and mixtures; and Organic peroxides (Type C. D.)
H250	Pyrophoric liquids; Pyrorophoric solids (Category 1)
H251	Self-heating substances and mixtures (Category 1)
H252	Self-heating substances and mixtures (Category 2)
H260	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 1)
H261	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 2)
H261	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 3)
H270	Oxidising gases (Category 1)
H271	Oxidising liquids;Oxidising solids (Category 1)
H272	Oxidising liquids;Oxidising solids (Category 2)
H280	Gases under pressure Compressed gas Liquefied gas Dissolved gas
H281	Gases under pressure Refrigerated liquefied gas
H290	Corrosive to Metals (Category 1)

H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
H305	Aspiration hazard (Category 2)
H310	Acute toxicity,dermal (Category 1, 2)
H311	Acute toxicity,dermal (Category 3)
H312	Acute toxicity,dermal (Category 4)
H313	Acute toxicity,dermal (Category 5)
H314	Skin corrosion/irritation (Category 1A, B, C)
H315	Skin corrosion/irritation (Category 2)
H316	Skin corrosion/irritation (Category 3)
H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
H319	Serious eye damage/eye irritation (Category 2A)
H320	Serious eye damage/eye irritation (Category 2B)
H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
H350	Carcinogenicity (Category 1A, 1B)
H351	Carcinogenicity (Category 2)
H360	Reproductive toxicity (Category 1A, 1B)
H361	Reproductive toxicity (Category 2)
H362	Reproductive toxicity, effects on or via lactation (Additional category)
H370	Specific target organ toxicity, single exposure (Category 1)
H371	Specific target organ toxicity, single exposure (Category 2)
H372	Specific target organ toxicity, repeated exposure (Category 1)
H373	Specific target organ toxicity, repeated exposure (Category 2)

H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
H410	Hazardous to the aquatic environment, long-term hazard(Category 1)
H411	Hazardous to the aquatic environment, long-term hazard (Category 2)
H412	Hazardous to the aquatic environment, long-term hazard (Category 3)
H413	Hazardous to the aquatic environment, long-term hazard (Category 4)
H420	Hazardous to the ozone layer (Category 1)

EHop-016

Product Details

Safety

Description

Related Products

Batch search Close

EHop-016 N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine

EHop-016
N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine