Rocilinostat (ACY-1215)
- Catalog NO.:A852479
- CAS No. : 1316214-52-4
- Molecular Formula:C24H27N5O3
- Molecular Weight: 433.50
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Product Details
CAS Number | 1316214-52-4 | Appearance | White powder |
Catalog Number | A852479 | MDL Number | MFCD22666356 |
Molecular Formula | C24H27N5O3 | Molecular Weight | 433.50 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 2-(DiphenylaMino)-N-[7-(hydroxyaMino)-7-oxoheptyl]-5-pyriMidinecarboxaMide;ACY-1215 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Rocilinostat, previously known as ACY-1215, is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells. |