ASP 3026
- Catalog NO.:A894976
- CAS No. : 1097917-15-1
- Molecular Formula:C29H40N8O3S
- Molecular Weight: 580.75
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Product Details
CAS Number | 1097917-15-1 | Appearance | Crystalline solid |
Catalog Number | A894976 | MDL Number | MFCD21609265 |
Molecular Formula | C29H40N8O3S | Molecular Weight | 580.75 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine;ASP3026 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3 and that of 3T3 cells expressing EML4-ALK variant 1, 2 and 3. The plasma and tumor concentrations of ASP3026 in mice xenografted with NCI-H2228 tumor were determined using high-performance liquid chromatography-tandem mass spectrometry. Significant tumor penetration was observed. |