Bosutinib
- Catalog NO.:A25014
- CAS No. : 380843-75-4
- Molecular Formula:C26H29Cl2N5O3
- Molecular Weight: 530.45
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 380843-75-4 | Appearance | Off-white powder |
Catalog Number | A25014 | MDL Number | MFCD07367846 |
Molecular Formula | C26H29Cl2N5O3 | Molecular Weight | 530.45 |
Boiling Point | 649.7±55.0°C at 760 mmHg | Melting Point | 137-147°C |
Flash Point | Density | 1.36 | |
Synonyms | SKI-606;4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | Not hazmat |
Hazard Statements | H319-H413 | Class | |
Precautionary Statements | P305+P351+P338 | Packing Group |
Description
Dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases. |