Baricitinib Phosphate

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For R&D use only.

Catalog NO.：A892930
CAS No. : 1187595-84-1
Molecular Formula：C₁₆H₂₀N₇O₆PS
Molecular Weight： 469.41

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	1187595-84-1	Appearance	White powder
Catalog Number	A892930	MDL Number	MFCD25976707
Molecular Formula	C₁₆H₂₀N₇O₆PS	Molecular Weight	469.41
Boiling Point		Melting Point
Flash Point		Density
Synonyms	2-[1-Ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile, phosphoric acid; NCB 028050;LY 3009104;INCB028050;LY3009104;LY-3009104;INCB-028050
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Baricitinib, also known as INCB-028050; INCB-28050; LY-3009104, is an oral highly selective JAK1 and JAK2 inhibitor for inflammatory and autoimmune diseases. There are four known JAK enzymes: JAK1, JAK2, JAK3 and TYK2. JAK-dependent cytokines have been implicated in the pathogenesis of a number of inflammatory and autoimmune diseases, suggesting that JAK inhibitors may be useful for the treatment of a broad range of inflammatory conditions. Baricitinib demonstrates approximately 100-fold greater potency of inhibition against JAK1 and JAK2 than JAK3 in kinase assays.

1187594-09-7 (free base)

1187595-84-1 (phosphate)

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire: Use … for extinction.
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