Filorexant

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Catalog NO.：A895178
CAS No. : 1088991-73-4
Molecular Formula：C₂₄H₂₅FN₄O₂
Molecular Weight： 420.48

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Product Details

CAS Number	1088991-73-4	Appearance
Catalog Number	A895178	MDL Number
Molecular Formula	C₂₄H₂₅FN₄O₂	Molecular Weight	420.48
Boiling Point		Melting Point
Flash Point		Density
Synonyms	MK 6096;((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone; 2-{2-[((2R,5R)-5-{[(5-fluoro-2-pyridinyl)oxy]methyl}-2-methyl-1-piperidinyl)carbonyl]-4-methylphenyl}pyrimidine; MK-6096; Filorexant [USAN]; UNII-E6BTT8VA5Z; MK6096; 2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methylpiperidin-1-yl)carbonyl)-4-methylphenyl)-pyrimidine; FILOREXANT; MK 6096; CHEMBL2107822; 2-{2-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrimidine; SureCN1716633; Filorexant (USAN);;MK-6096
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements		Class
Precautionary Statements		Packing Group

Description

Filorexant, also known as MK6096, is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. MK-6096 demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes. MK-6096 occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM, and dose-dependently reduced locomotor activity and significantly increased sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg)

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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P370 + P378	In case of fire: Use … for extinction.
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P501	Dispose of contents/container to..…
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Filorexant

Product Details

Safety

Description

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H313	Acute toxicity,dermal (Category 5)
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H318	Serious eye damage/eye irritation (Category 1)
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