Setanaxib
- Catalog NO.:A891302
- CAS No. : 1218942-37-0
- Molecular Formula:C21H19ClN4O2
- Molecular Weight: 394.86
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Product Details
CAS Number | 1218942-37-0 | Appearance | Light yellow powder |
Catalog Number | A891302 | MDL Number | MFCD27923122 |
Molecular Formula | C21H19ClN4O2 | Molecular Weight | 394.86 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione;GKT-137831 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H332-H335 | Class | |
Precautionary Statements | P280-P305+P351+P338-P310 | Packing Group |
Description
GKT137831, also known as GTK831, is a novel and potent Nox4 inhibitor. GKT137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies. |