For R&D use only.

Setanaxib

  • Catalog NO.:A891302
  • CAS No. : 1218942-37-0
  • Molecular Formula:C21H19ClN4O2
  • Molecular Weight: 394.86
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Quality Control&SDS
SDS COA NMR

Product Details

CAS Number 1218942-37-0 Appearance Light yellow powder
Catalog Number A891302 MDL Number MFCD27923122
Molecular Formula C21H19ClN4O2 Molecular Weight 394.86
Boiling Point Melting Point
Flash Point Density
Synonyms 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione;GKT-137831
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302-H315-H319-H332-H335 Class
Precautionary Statements P280-P305+P351+P338-P310 Packing Group

Description

GKT137831, also known as GTK831, is a novel and potent Nox4 inhibitor. GKT137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.

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Setanaxib
2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione;GKT-137831