Necrostatin-1
- Catalog NO.:A826160
- CAS No. : 4311-88-0
- Molecular Formula:C13H13N3Os
- Molecular Weight: 259.33
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 4311-88-0 | Appearance | Yellow powder |
Catalog Number | A826160 | MDL Number | MFCD00056916 |
Molecular Formula | C13H13N3Os | Molecular Weight | 259.33 |
Boiling Point | 441.9°C at 760 mmHg | Melting Point | 151℃ |
Flash Point | 93.3℃ | Density | |
Synonyms | 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-imidazolidin-4-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H317 | Class | |
Precautionary Statements | P280 | Packing Group |
Description
ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke. |