Ro 3306
- Catalog NO.:A857702
- CAS No. : 872573-93-8
- Molecular Formula:C18H13N3Os2
- Molecular Weight: 351.45
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 872573-93-8 | Appearance | |
Catalog Number | A857702 | MDL Number | MFCD17392573 |
Molecular Formula | C18H13N3Os2 | Molecular Weight | 351.45 |
Boiling Point | 569.1±60.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis. |