Cyclophosphamide

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For R&D use only.

Catalog NO.：A853095
CAS No. : 50-18-0
Molecular Formula：C₇H₁₁Cl₂N₂O₂P
Molecular Weight： 257.05

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Product Details

CAS Number	50-18-0	Appearance
Catalog Number	A853095	MDL Number	MFCD00005978
Molecular Formula	C₇H₁₁Cl₂N₂O₂P	Molecular Weight	257.05
Boiling Point	336.1°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	Bis-(2-chloro-ethyl)-(2-oxo-2H-2l5-[1,3,2]oxazaphosphinin-2-yl)-amine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	2811
Hazard Statements	H301-H350	Class	6.1
Precautionary Statements	P201-P301+P310-P308+P313	Packing Group	Ⅲ

Description

Nitrogen mustard alkylating agent and prodrug. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Inhibits aldehyde dehydrogenase 1 (ALDH1) through its degradation product acrolein. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered with etoposide (Cat. No. 1226) in breast cancer cell lines.

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P265	Wash skin thouroughly after handling.
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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire: Use … for extinction.
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