HG-10-012-01
- Catalog NO.:A887737
- CAS No. : 1351758-81-0
- Molecular Formula:C17H20ClN5O3
- Molecular Weight: 377.83
Note*
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
SDS
Product Details
CAS Number | 1351758-81-0 | Appearance | White to off-white solid |
Catalog Number | A887737 | MDL Number | MFCD28160565 |
Molecular Formula | C17H20ClN5O3 | Molecular Weight | 377.83 |
Boiling Point | 641.1±65.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | [4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone;HG-10-102-01 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Brain-permeable. HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC₅₀ values are ~20.3 nM and ~ 3.2 nM, respectively). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells. May be a useful tool for Parkinson’s Disease research. |